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(GaxIn1−x)2O3薄膜；带隙可调谐；磁控溅射 1

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Clinical characteristics and prognostic values of 1p32.3 deletion detected through fluorescence

Huanping Wang, Haitao Meng, Jinghan Wang, Yinjun Lou, Yile Zhou, Peipei Lin, Fenglin Li, Lin Liu, Huan Xu, Min Yang, Jie Jin

《医学前沿（英文）》 2020年第14卷第3期页码 327-334 doi: 10.1007/s11684-019-0712-x

摘要： This study aimed to investigate the prevalence, clinical characteristics, and prognostic impact of 1p32.3 deletion in patients with newly diagnosed multiple myeloma (MM). A retrospective analysis was conducted on 411 patients with newly diagnosed MM; among which, 270 received bortezomib-based therapies, and 141 received thalidomide-based therapies. Fluorescence hybridization (FISH) was performed to detect six cytogenetic abnormalities, namely, del(1p32.3), gain(1q21), del(17p13), del(13q14), t(4;14), and t(11;14). Results showed that 8.3% of patients with MM were detected with del(1p32.3) and had significantly more bone marrow plasma cells ( = 0.025), higher 2-microglobulin levels ( = 0.036), and higher lactate dehydrogenase levels ( = 0.042) than those without del(1p32.3). Univariate analysis showed that patients with del(1p32.3) under thalidomide-based therapies (median PFS 11.6 vs. 31.2 months, = 0.002; median OS 16.8 vs. 45.9 months, <0.001) were strongly associated with short progression-free survival (PFS) ( = 0.002) and overall survival (OS) ( <0.001). Multivariate analysis revealed that del(1p32.3) remained a powerful independent factor with worse PFS ( = 0.006) and OS ( = 0.016) for patients under thalidomide-based treatments. Patients with del(1p32.3) under bortezomib-based treatments tended to have short PFS and OS. In conclusion, del(1p32.3) is associated with short PFS and OS in patients with MM who received thalidomide- or bortezomib-based treatments.

关键词： 1p32.3 deletion 1q21 gain prognosis multiple myeloma FISH bortezomib thalidomide

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Hot deformation behavior of a novel bimetal consisting of BTW1 and Q345R characterized by processing

Pengtao LIU, Lifeng MA, Weitao JIA, Tao WANG, Guanghui ZHAO

《机械工程前沿（英文）》 2019年第14卷第4期页码 489-495 doi: 10.1007/s11465-019-0554-x

摘要： Only a few studies have been conducted on the flow behavior of the novel BTW1/Q345R bimetal, which is widely used in coal equipment. In this work, compression tests were conducted on BTW1/Q345R bimetal at a temperature range of 950 °C–1200 °C and strain rates of 0.05, 0.5, 5, and 15 s by using a Gleeble-3800 thermomechanical simulator. A constitutive equation was validated by referring to the Arrhenius equation during the characterization of hot workability. The computed apparent activation energy of the BTW1/Q345R bimetal was 360 kJ/mol, and processing maps under different strain conditions were drawn. Analysis of the stress-strain relationship revealed that work hardening exerted a dominant effect on the thermal deformation of the BTW1/Q345R bimetal. The processing maps predicted that the optimal processing interval will increase with strain. Results showed that thermal deformation of the BTW1/Q345R bimetal should proceed when the temperature range varies from 1182 °C to 1200 °C and the strain rate interval is from 4.2 to 15 s .

关键词： BTW1/Q345R bimetal constitutive equation processing map work hardening

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二硫化铼超薄纳米片的制备及其在调Q掺铒光纤激光器中的应用 Research

何俊杉1,2,3,4,曾国华1,刘绍贤1,卢海明1,谢锐贤1,戚晶晶1, 陶丽丽1,周博2,3,4

《信息与电子工程前沿（英文）》 2021年第22卷第3期页码 287-436 doi: 10.1631/FITEE.2000339

摘要：本文通过液相剥离法从自制二硫化铼粉末中制备二硫化铼超薄纳米片，并将其应用在调Q掺铒光纤激光器中。将二硫化铼/PVA复合薄膜作为可饱和吸收体放入掺铒光纤激光器中可以获得调Q脉冲输出，脉冲宽度最窄为2.4 μs，输出功率为1.25 mW，揭示了二硫化铼在Q调制方面的潜在应用价值。

关键词：二硫化铼；可饱和吸收体；二维材料；调Q光纤激光器

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PAK1 is a novel cardiac protective signaling molecule

null

《医学前沿（英文）》 2014年第8卷第4期页码 399-403 doi: 10.1007/s11684-014-0380-9

摘要：

We review here the novel cardiac protective effects of the multifunctional enzyme, p21-activated kinase 1 (PAK1), a member of a serine/threonine protein kinase family. Despite the large body of evidence from studies in noncardiac tissue indicating that PAK1 activity is key in the regulation of a number of cellular functions, the role of PAK1 in the heart has only been revealed over the past few years. In this review, we assemble an overview of the recent findings on PAK1 signaling in the heart, particularly its cardiac protective effects. We present a model for PAK1 signaling that provides a mechanism for specifically affecting cardiac cellular processes in which regulation of protein phosphorylation states by protein phosphatase 2A (PP2A) predominates. We discuss the anti-adrenergic and antihypertrophic cardiac protective effects of PAK1, as well as its role in maintaining ventricular Ca²⁺ homeostasis and electrophysiological stability under physiological, β-adrenergic and hypertrophic stress conditions.

关键词： p21-activated kinase 1 (PAK1) heart

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CD117^dim/CD34⁺CD117^bri myeloblast-associated gene expression in t(8;21

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

《医学前沿（英文）》 2021年第15卷第4期页码 608-620 doi: 10.1007/s11684-021-0836-7

摘要： t(8;21)(q22;q22) acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy with a high relapse rate in China. Two leukemic myeloblast populations (CD34 CD117 and CD34 CD117 ) were previously identified in t(8;21) AML, and CD34 CD117 cell proportion was determined as an independent factor for this disease outcome. Here, we examined the impact of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression on t(8;21) AML clinical prognosis. In this study, 85 patients with t(8;21) AML were enrolled. The mRNA expression levels of CD34 CD117 -associated genes ( , , and ) and CD34 CD117 -associated genes ( , , and ) were measured using quantitative reverse transcription PCR. Associations between gene expression and clinical outcomes were determined using Cox regression models. Results showed that patients with high , , or expression had significantly inferior overall survival (OS), whereas those with high or expression showed relatively favorable prognosis. Univariate analysis revealed that CD19, CD34 CD117 proportion, mutation, minimal residual disease (MRD), and expression levels of , , , and were associated with OS. Multivariate analysis indicated that mutation, MRD and and expression levels were independent prognostic variables for OS. Identifying the clinical relevance of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression may provide new clinically prognostic markers for t(8;21) AML.

关键词： t(8 21)(q22 q22) AML CD34⁺CD117^dim/ CD34⁺CD117^bri cell population gene expression prognosis

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Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

《医学前沿（英文）》 2019年第13卷第3期页码 388-397 doi: 10.1007/s11684-018-0624-1

摘要： Collaboration of c-KIT mutations with AML1–ETO (AE) has been demonstrated to induce t(8; 21) acute myeloid leukemia (AML). Targeted therapies designed to eliminate AE and c-KIT oncoproteins may facilitate effective treatment of t(8; 21) AML. Homoharringtonine (HHT) features activity against tumor cells harboring c-KIT mutations, whereas oridonin can induce t(8; 21) AML cell apoptosis and AE cleavage. Therefore, studies should explore the efficacy of combination therapy with oridonin and HHT in t(8; 21) AML. In this study, we investigated the synergistic effects and mechanism of oridonin combined with HHT in t(8; 21) AML cell line and mouse model. The two drugs synergistically inhibited cell viability and induced significant mitochondrial membrane potential loss and apoptosis. Oridonin and HHT induced significant downregulation of c-KIT and its downstream signaling pathways and promoted AE cleavage. HHT increased intracellular oridonin concentration by modulating the expressions of MRP1 and MDR1, thus enhancing the effects of oridonin. The combination of oridonin and HHT prolonged t(8; 21) leukemia mouse survival. In conclusion, oridonin and HHT exert synergistic effects against t(8; 21) leukemia and , thereby indicating that their combination may be an effective therapy for t(8; 21) leukemia.

关键词： AML1–ETO c-KIT homoharringtonine oridonin t(8 21) AML synergistic effect

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基于拓扑绝缘体Sb2Te3的52 nm宽谱可调谐被动调Q掺镱光纤激光器 Research

王涛1,俞强1,2,郭琨1,史鑫尧2,阚雪芬3,徐轶君4,5,吴坚1,4,张凯2,周朴1

《信息与电子工程前沿（英文）》 2021年第22卷第3期页码 287-436 doi: 10.1631/FITEE.2000577

摘要：在本研究中，首先将拓扑绝缘体家族中的二维材料Sb2Te3可饱和吸收体应用在宽谱可调谐被动调Q掺镱光纤激光器中。基于此可饱和吸收体，在掺镱光纤环形腔中获得稳定的波长可调谐被动调Q脉冲，其中心波长可从1040.89 nm连续调节到1092.85 nm。

关键词：拓扑绝缘体；Sb2Te3；光纤激光；被动调Q激光；波长可调谐激光

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线性离散时间系统H∞控制的极小极大Q-学习设计 Research Articles

李新兴1,奚乐乐2,3,查文中1,彭志红2

《信息与电子工程前沿（英文）》 2022年第23卷第3期页码 438-451 doi: 10.1631/FITEE.2000446

摘要：为求解涉及的博弈代数黎卡提方程，在离线策略算法基础上提出一种新型无模型极小极大Q-学习算法，并证明离线策略迭代算法是求解博弈代数黎卡提方程的牛顿法。提出的极小极大Q-学习算法采用离轨策略强化学习技术，利用行为策略产生的系统状态数据，可实现对最优控制器和最佳干扰策略的在线学习。不同于当前Q-学习算法，本文提出一种基于梯度的策略提高方法。证明在一定持续激励条件下，对于初始可行的控制策略并结合合适学习率，提出的极小极大Q-学习算法可收敛到鞍点策略。将提出的极小极大Q-学习算法用于受负载扰动的电力系统H∞负载频率控制器设计，仿真结果表明，最终得到的H∞负载频率控制器具有良好抗干扰性能。

关键词： H∞控制；零和动态博弈；强化学习；自适应动态规划；极小极大Q-学习；策略迭代

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Gain-enhanced reconfigurable radiation array with mechanically driven system and directive elements

《机械工程前沿（英文）》 2022年第17卷第4期 doi: 10.1007/s11465-022-0716-0

摘要： In the artificial intelligence-driven modern wireless communication system, antennas are required to be reconfigurable in terms of size according to changing application scenarios. However, conventional antennas with constant phase distributions cannot achieve enhanced gains in different reconfigurable sizes. In this paper, we propose a mechanically reconfigurable radiation array (RRA) based on miniaturized elements and a mechanically reconfigurable system to obtain gain-enhanced antennas in compact and deployed states. A five-element RRA with a phase-reconfigurable center element is designed and analyzed theoretically. The experimental sample has been fabricated, driven by a deployable frame with only one degree of freedom to realize the size and phase distribution reconfiguration simultaneously to validate the enhanced gains of RRA. The proposed RRA can be tessellated into larger arrays to achieve higher gains in other frequency regimes, such as terahertz or photonics applications with nanometer fabrication technology.

关键词： mechanism reconfigurable radiation array (RRA) compact state deployed state enhanced gain

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特定领域问答网站中的标签自然顺序研究

贾俊芳1,李国强2

《信息与电子工程前沿（英文）》 2021年第22卷第2期页码 141-286 doi: 10.1631/FITEE.1900645

摘要：标注是Web 2.0的一个重要特征。它使得社会计算系统（如问答网站）的用户们可以自由地标记内容。然而，标注真的是自由不受限的吗？现有工作表明，用户们常常可以隐性地就哪种标签最能描述在线社区的内容达成共识。然而，目前还没有针对用户在标注过程中对标签排序的规律性开展研究。本文专注于研究特定领域问答网站中的标签自然排序，并对CodeProject，SegmentFault，Biostars以及CareerCup 4个问答网站上数以百万计的问题中的标签序列进行研究。结果表明，这些问答网站的用户可以就问题标签的排序达成隐性共识。研究了标签之间的关系，这些关系可以解释标签自然顺序的出现。该研究为利用标签的自然顺序提升现有标签推荐以及问答站点导航提供了可能。

关键词：问答网站；标注；自然顺序；Skip gram

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AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

null

《医学前沿（英文）》 2012年第6卷第3期页码 248-262 doi: 10.1007/s11684-012-0206-6

摘要：

The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is present in approximately 4%–12% of adult and 12%–30% of pediatric acute myeloid leukemia (AML) patients. Both human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesis in the absence of secondary events. In this review, we discuss the pathogenetic insights that have been gained from identifying the various events that can cooperate with AML1-ETO to induce AML in vivo. We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting the fusion protein itself, the proteins that bind to it, or the genes that it regulates. Recently published studies suggest that a targeted therapy for t(8;21) positive AML is feasible and may be coming sometime soon.

关键词： AML1-ETO mouse model leukemia t(8 21) pathway hits mutation hematopoiesis Kasumi-1 CD34+

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Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

《结构与土木工程前沿（英文）》 2014年第8卷第4期页码 448-455 doi: 10.1007/s11709-014-0262-x

摘要： Rock mass classification system is very suitable for various engineering design and stability analysis. classification method is confirmed by Japan Highway Public Corporation that this method can figure out either strength or deformability of rock mass, further appropriating the amount of rock bolts, thickness of shotcrete, and size of pitch of steel ribs just after the blasting procedure. Based on these advantages of method, in this study, according to data of five deep and long tunnels in Iran, two equations for estimating the value of method from and classification systems were developed. These equations as a new method were able to optimize the support system for and classification systems. From classification and its application in these case studies, it is pointed out that the method for the design of support systems in underground working is more reliable than the and classification systems.

关键词： JH classification Q and RMR classification new method

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A reversibility-gain model for integer Karhunen-Loève transform design in video coding

Xing-guo ZHU,Lu YU

《信息与电子工程前沿（英文）》 2015年第16卷第10期页码 883-891 doi: 10.1631/FITEE.1500071

摘要： Karhunen-Loève transform (KLT) is the optimal transform that minimizes distortion at a given bit allocation for Gaussian source. As a KLT matrix usually contains non-integers, integer-KLT design is a classical problem. In this paper, a joint reversibility-gain (R-G) model is proposed for integer-KLT design in video coding. Specifically, the ‘reversibility’ is modeled according to distortion analysis in using forward and inverse integer transform without quantization. It not only measures how invertible a transform is, but also bounds the distortion introduced by the non-orthonormal integer transform process. The ‘gain’ means transform coding gain (TCG), which is a widely used criterion for transform design in video coding. Since KLT maximizes the TCG under some assumptions, here we define the TCG loss ratio (LR) to measure how much coding gain an integer-KLT loses when compared with the original KLT. Thus, the R-G model can be explained as follows: subject to a certain TCG LR, an integer-KLT with the best reversibility is the optimal integer transform for a given non-integer-KLT. Experimental results show that the R-G model can guide the design of integer-KLTs with good performance.

关键词： Integer transform Karhunen-Loè ve transform (KLT) Integer-KLT Transform coding Video coding

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An approach for evaluating fire resistance of high strength Q460 steel columns

Wei-Yong WANG, Guo-Qiang LI, Bao-lin YU

《结构与土木工程前沿（英文）》 2014年第8卷第1期页码 26-35 doi: 10.1007/s11709-014-0239-9

摘要： To develop a methodology for evaluating fire resistance of high strength Q460 steel columns, the load bearing capacity of high strength Q460 steel columns is investigated. The current approach of evaluating load bearing capacity of mild steel columns at room temperature is extended to high strength Q460 steel columns with due consideration to high temperature properties of high strength Q460 steel. The critical temperature of high strength Q460 steel column is presented and compared with mild steel columns. The proposed approach was validated by comparing the predicted load capacity with that evaluated through finite element analysis and test results. In addition, parametric studies were carried out by employing the proposed approach to study the effect of residual stress and geometrical imperfections. Results from parametric studies show that, only for a long column (slenderness higher than 75), the magnitude and distribution mode of residual stress have little influence on ultimate load bearing capacity of high strength Q460 steel columns, but the geometrical imperfections have significant influence on any columns. At a certain slenderness ratio, the stability factor first decreases and then increases with temperature rise.

关键词： high strength Q460 steel load bearing capacity temperature